This file gives you the description of all the headers in the file consisting of the predictions for the SNPs in GPCRs in dbSNP. refsnp_id The id for a SNP in dbSNP name Name of the GPCR protein as seen in SWISS-PROT and GPCRDB aa1, aa2 The two amino acid variations corresponding to the different alleles aapos The amino acid residue number corresponding to the SNP domain Location of the SNP (transmembrane, extracellular, intracellular, N-terminus or C-terminus) ss Transmembrane is denoted by 2 and the non-transmembrane regions by 1 abs(deltavol) Absolute change in volume of side-chain due to SNP SIFT Score obtained using default settings of SIFT abs(delta(ges)) Change in free energy of hydropathy ion the GES scale due to SNP abs(delhyd) Change in hydrophobicity using the Kyte-Doolittle scale due to SNP nor_entropy Normalized site entropy abd(delrf) Change in residue frequency log(p/(1-p)) Log odds ratio calculated as in Equation 1 (see text) as part of the logistic regression analysis LR_prediction The predictions obtained based on the above log odds value using logistic regression analysis -------------------------------------------------------------------------------------------------- Note: For SNPs in non-transmembrane regions, the PHAT score column will have no value and hence has a value "?". For SNPs in non-transmembrane regions, the abs(delta(ges)) column will have no value and hence has a value "?".