CB&B752/CPSC452/CPSC752/ MB&B452/MB&B752/MCDB452/MCDB752

BIOINFORMATICS: Main Points

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Main Points

Bioinformatics Section
17 MG Bioinformatics: Overview
  • Definition of bioinformatics,
  • examples of data,informatics techniques, and applications
19 MG Overview Continued
  • Boundaries of bioinformatics
24 MG Analysis of Sequences I
  • Dynamic programming,
  • pair wise sequence alignment,
  • substitution matrices,
  • multiple sequence alignment,
  • profiles, motifs, hidden Markov models,
  • p-values in relation to scoring alignments,
  • extreme value distributions
26 MG Analysis of Sequences II
31 MG Analysis of Sequences III
Nov 02 MG Demonstration of Web Resources
  • Semantic Web
  • Data Heterogeneity
  • XML, RDF, and LSIDs
  • Examples of semantic web applications
07 MG Analysis of Sequences IV
  • Computational Complexity
  • ROC Plots
  • Heuristic approaches to sequence alignment, FastA, Blast, and improvements
  • Problems that arise when using a database
  • Secondary structure, simplified picture with TM helices
  • GOR
  • Threading/Fold recognition
09 MG Structures I
  • Protein geometry and structure
  • Comparison of 2 structures
  • Differences between sequence and structure alignment techniques
  • Dynamic programming difficulties
16 MG Structures II
28 MG Structures III
30 MG Simulation
  • Main forces with concerns to macromolecules
  • Major simulation methods
  • Major approximations used with macromolecules
  • Details about minimizaiton